Familial cancers
نویسندگان
چکیده
منابع مشابه
Familial gastrointestinal carcinoid tumours and associated cancers.
BACKGROUND Carcinoid tumours are neuroendocrine neoplasms mainly located in the gastrointestinal tract and bronchopulmonary system. Our study's aim was to characterise the familial nature of gastrointestinal carcinoid tumours using the Swedish Family-Cancer Database, which includes >11.5 million individuals. METHODS Familial relative risks (RRs) of carcinoid tumours were estimated for individ...
متن کاملEpigenetic alterations in sporadic and familial cancers
10 INTRODUCTION 12 REVIEW OF THE LITERATURE 13 1 Epigenetics overview 13 1.1 DNA methylation 14 1.2 Post-translational histone modifications and chromatin remodeling 16 1.3 Noncoding RNAs and RNA interference 17 1.4 Interplay between different epigenetic factors 18 1.5 Epigenetic inheritance 19 2 Basic characteristics of cancer 20 3 Cancer genetics 23 3.1 Tumor suppressor genes 23 3.2 Oncogenes...
متن کاملSecond primary cancers after sporadic and familial colorectal cancer.
Second cancers were studied among 68,104 cases of colorectal cancer (CRC) from the Swedish Family-Cancer Database. A total of 1,113 patients received a diagnosis of second CRC; 25 of them had a family history of CRC. Cases of second CRC with a family history were diagnosed up to 10 years before sporadic cases. The relative risk (RR) of all second CRCs was 2.21 compared with the first CRC. Famil...
متن کاملGenetic and epigenetic alterations of familial pancreatic cancers.
BACKGROUND Little is known about the genetic and epigenetic changes that contribute to familial pancreatic cancers. The aim of this study was to compare the prevalence of common genetic and epigenetic alterations in sporadic and familial pancreatic ductal adenocarcinomas. METHODS DNA was isolated from the microdissected cancers of 39 patients with familial and 36 patients with sporadic pancre...
متن کاملMicrosatellite instability differences between familial and sporadic ovarian cancers.
DNA instability, reflected in altered patterns of short tandem repeat sequences (microsatellites) in dividing cells, has been described in hereditary non-polyposis colon cancer (HNPCC) and in other tumor types. Ovarian cancer (OC), although most often a sporadic cancer, can recur, with HNPCC, as part of the Lynch cancer family syndrome. In an investigation of microsatellite instability (MIN) in...
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ژورنال
عنوان ژورنال: Nature
سال: 1984
ISSN: 0028-0836,1476-4687
DOI: 10.1038/307116c0